Month: May 2023

Thank you for a fabulous 2023 CSC Symposium!

Posted on by Beverley Rabbitts

The Grand (Re) Opening Celebration & Research Symposium on May 5, 2023 was a marvelous success. Thank you to everyone who came, interacted, presented research, or showcased technologies.

The event was held in the beautiful University Center venue. Scott Lokey and Phil Crews presented some entertaining stories from the beginnings of the CSC. We also had on stage Paul Koch, the Dead of the PBSci division.

Trainees flaunted their research success with talks, posters, and a number of fun prizes. Trainee talks were given by Aswad Khadilkar, Jaru Taechalertpaisarn, and Cindy Liang. The first place poster prize was tied between Tilini Wijeratne and Peter Ngoi, and third place was awarded to Nadia Dzhanbekova. Recognized for their excellence in High Throughput Technology were instrument users Matylda Zietek, Priya Crosby, Jaru Taechalertpaisarn, Matt Loven, Jackson Baumgartner, Adam Lentz, and Akshar Lohith.

We had a lovely catered party at the end of the day, where we heard from Cynthia Larive, Chancellor of the University, who recognized the ways that the CSC supports inspiring, high impact research that improves lives for the better.

Thank you to Jack Lee for being our photographer for the symposium!

We also want to thank our industry sponsors, primarily Perkin Elmer, whose donation funded the majority of the event. We also had vendor tables from Agilent BioTek and BioLegend. We also thank our internal symposium sponsors, the Office of Research; the PBSci Division Dean’s Office; Department of Chemistry & Biochemistry; Department of Molecular, Cellular, and Developmental Biology; Department of Microbiology and Environmental Toxicology; and the Biomolecular Engineering department within Baskin Engineering.

Last but not least, we thank QB3 and the UCSC Physical and Biological Sciences Division for ongoing support of the CSC daily operations.

CSC Symposium is in the UCSC news

Posted on by Beverley Rabbitts

newscenter screenshot with the article title and picture of users at the microscope

“Rabbitts provides one-on-one training for students and other new users of the center’s facilities. Lokey said the focus on training sets the UCSC center apart from other screening centers.

“It’s valuable experience for the students, and the symposium will give them an opportunity to showcase what they’ve been doing,” he said.”

 

Full article: https://news.ucsc.edu/2023/04/csc-symposium.html

Research in Progress Presentations at the 2023 CSC Symposium

Posted on by Beverley Rabbitts

Poster session 1

Ben Abrams, academic/research staff – Life Sciences Microscopy Center. The UCSC Life Sciences Microscopy Center Has Tools for Your Research
Nadia Dzhanbekova, graduate student – Seth Rubin. Chemical Library Screening to Identify Novel Molecular Mechanisms Behind Cell Cycle Arrest
Sahar Hosseinzadeh, graduate student – John MacMillan. Identification of Selective Cytotoxins for Non-Small Cell Lung Cancer Cell Lines
Karen Hug, graduate student – Victoria Auerbuch Stone. Disruption of the Yersinia pseudotuberculosis T3SS primes bacteria for envelope stress
Rachel Jacobson, Senior Director Research – Spring Discovery. Using Machine Learning to Harness the Complexities of Inflammasome Biology for Novel Drug Discovery
*Aswad Khadilkar, academic/research staff – John MacMillan. Assigning Mechanism of Action To Natural Products In Multiple Biological Contexts Using Gene Expression And Phenotypic Screening Methods Established By The HIFAN Program
*Cindy Liang, graduate student – Angela Brooks. Pairing phenotypic assays with direct RNA sequencing to understand U2AF1 S34F and cigarette smoke’s functional role in lung cancer
Akshar Lohith, PhD Candidate – Scott Lokey and John MacMillan. Advancing Cell Profiling to cover a broad phenotypic space and determine the mechanism of action of diverse perturbations

Poster session 2

Gabe Mitchell, industry. Open Innovation @ NITD: targeting the host-pathogen interface during microbial infection
Joseph Morris, lab of Tyler Johnson, Dominican University of California. In Vivo Evaluation of Zampanolide & Thermolysis Reveals Cytotoxicity of Hemi-Aminal Side Chain & Delayed Binding Mode of Dactylolide
Samuel Mussetter, undergraduate student – Crews Lab. Further Evaluation of a Bicyclic Pyrazolines as a 15-Lipoxygenase V-Type Activators – Scrutizining Their 3D Properties
Peter Ngoi, graduate student – Seth Rubin. Structural basis for E2F1 Recognition by E3 Ligase SCF-CyclinF
Beverley Rabbitts, core director of CSC. High content screening and machine learning for identifying novel natural product modulators of the innate immune response.
Francesco Rubbo, industry researcher – Spring Discovery. A Benchmark Dataset for Phenotypic Compound Similarity in Inflammasomes Screens
Diksha Sharma, graduate student – Carrie Partch. Small-molecule screening:PASsing the binding test
*Jaru Taechalertpaisarn, post-doc – Scott Lokey. Discovery of Novel Active Macrocyclic Peptides Through Permeable-First Perspective
Tilini Wijeratne, graduate student – Seth Rubin. B-Myb association with DNA is regulated by its Negative regulatory domain and Cdk phosphorylation
Kevin Yang, graduate student – Scott Lokey. Development and Characterization of Passively Cell-Permeable RNA-Binding Cyclic Peptides

*=giving a talk (plus or minus poster) with this title. The rest are posters only.